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This is a theoretical concern raised by the biology, not a demonstrated harm in humans for either compound, and it should be described as exactly that an unresolved question that the absence of long-term human data leaves open, not a proven risk and not a reason for false reassurance either

However, treatment with NS oil could not ameliorate the serum glucose level to normal value despite restoring the insulin level in diabetic rats ( Anti-inflammatory effects Diabetes induced-oxidative damage may create ripple effects that trigger widespread inflammatory reactions, which further exacerbate the damage to the tissues

Physico-chemical stability of colloidal lipid particles

Thus, we speculate that NRF2-mediated GSTA4 detoxification may play a role in estrogen-mediated neuroprotection and sex differences in hearing and longevity