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A double-blind, randomized, placebo-controlled, single-ascending-dose (2.5, 5, 7.5, and 10 g) study was conducted to assess the safety, tolerability, and pharmacokinetics of hydroxocobalamin in 136 healthy adult subjects

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Confirmed decline of NAD+ associated with cognitive decline, sarcopenia, and metabolic disease, and reviewed compound-based strategies for NAD+ modulation via NAMPT activation, CD38 inhibition, and PARP inhibition