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How to Treat and Prevent Vitamin B12 Deficiency The mode of treatment is dependent on the cause

Common Vitamin B12 deficiency symptoms include fatigue, brain fog, weakness, numbness or tingling in the hands and feet, and mood changes

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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases showed that B12 deficiency symptoms can be seen even when B12 level in blood is within the reference range, as 200 900 pg/mL in the United States,2 and 135-650 pmol/L in Australia.3 In clinical practice, signs and symptoms of B12 deficiency start when plasma B12 levels are normal, and long historical studies showed that neurological symptoms of deficiency occur in patients without sign of anaemia