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The subsequent increase in urinary melatonin excretion in cataract surgery subjects may be another example where the reduced utilization of melatonin for solubilizing and clearing cataractous amyloid aggregates in the crystalline lens via the ocular glymphatic system results in elevated circulatory/excretion melatonin levels [65, 210, 211]

Stearns AT, Balakrishnan A, Rhoads DB, Ashley SW, Tavakkolizadeh A (2008) Diurnal rhythmicity in the transcription of jejunal drug transporters

Cell 138, 449462

Selank exerts its effects primarily through modulation of GABA, serotonin, and dopamine pathways, which together regulate mood, anxiety response, and emotional balance