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This mechanism not only reshapes the immunosuppressive state of the tumor microenvironment but also provides key targets for breaking immune tolerance and improving the efficacy of immunotherapy

Curcumin upregulates PGC-1 via AMPK signaling, subsequently enhancing PPAR activity and Superoxide Dismutase-2 (SOD-2) transcription/activity, thereby suppressing 1(I) collagen expression in cultured HSCs (Zhai et al., 2015)