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Search strategy The PubMed, Scopus, and Web of Science (WoS) databases were searched using four combinations of Medical Subject Headings (MeSH) keywords (presented in Table 1 in the Results section)

Tianma modulates (ER-resident) molecular chaperone proteins in differentiated neuronal N2a cells Skp1a : Decreased expressions of the ubiquitin-proteasome/E3 ligase component Skp1a and the chaperone Hsc-70 can lead to a wide impairment in the function of an entire repertoire of proteins in neurons [60] suggesting a new structural role of Skp1a in dopaminergic neuronal functions besides its E3 ligase activity [61]

Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)

PET tracers targeting transferrin receptors underperform in diffuse axonal injury, as injury boundaries are unclear and non-specific uptake occurs in perihematomal edema, resulting in signal levels below clinical detection thresholds