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In an expert panel review of deaths caused by cough and cold medications, supratherapeutic doses were identified in most of the fatal cases.16 One factor that was thought to contribute to overdoses was the lack of an appropriate device to administer the medication.16 , 17 Spoons are often used by parents, but are inaccurate,17 as are liquid droppers

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And a 2015 safety-pharmacology study of a different, related ghrelin-receptor agonist found dose-dependent heart-muscle damage in rats after 28 days of dosing ipamorelin itself was not the compound tested, but the finding is treated in the literature as a class-level signal worth keeping in mind for any chronic ghrelin-receptor agonist [12]