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For instance, with respect to the effect on nucleus pulposus cells (NPCs), m 6 A-mediated methylation by abnormally elevated METTL3 enhances the stability and expression of SIAH1 mRNA, which targets and ubiquitinates XIAP, promoting aging and apoptosis [192]

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It has been suggested that the reduced inhibition of PR3 due to A1ATD may lead to increased production of PR3-directed C-ANCA autoantibodies

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IV infusions are administered at 5mg/kg at weeks 0, 2 and 6 reducing to every 8 weeks thereafter

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