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Rats of the control group received 100 L of PBS injected at the same time each week

When PLOOH is not rapidly neutralized as an PLOH by glutathione peroxidase 4 (GPX4) in time, PLOOH further reacts with ferrous ions, and the resulting lipid radicals, such as alkoxyl phospholipid radicals (PLO) and PLOO, react with PUFA-PLs ( 2 produced by the mitochondrial tricarboxylic acid (TCA) cycle and the reduction of nitrogen oxides by NADPH produce H 2 O 2 catalyzed by superoxide dismutase (SOD) and participate in the Fenton reaction of iron ( Figure 1A )

Paradowska E, Hara DA, Kania KD, Jarych D, Wilczyski M, Malinowski A, Kawecka M, Nowak M, Wilczyski JR

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