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Clinical Classification of Chronic Venous Disease C0: No visible or palpable sign of venous disease C1: Telangiectasias (spider veins) or reticular veins (veins that feed spider veins) C2: Varicose veins C3: Edema (swelling) C4: Changes in skin and tissues underneath the skin A: Pigmentation or eczema B: Thickening, hardening, swelling, redness, inflammation, scarring C5: Healed venous ulcer C5: Healed venous ulcer C6: Active venous ulcer It is important to note that some potential complications of venous disease, such as deep vein thrombosis, can occur even in people who have no overt signs corresponding with any of the aforementioned stages

Treatment generally consists of supportive care

Anti inflammatory and antioxidant signaling Evidence sources : cell and animal work, narrative and mechanistic reviews Confidence : moderate on signaling changes Main caveats : shifts in biomarkers are not the same as demonstrated clinical benefit

6), similar to our mouse model of atherosclerosis (Fig