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Patient subgroups, characterized by distinct symptom profiles and comorbidities, exhibited increased responses to specific treatments, e.g., a POTS-dominant cluster benefiting from autonomic modulators and a cognitive-dysfunction cluster from CNS stimulants

27 The authors also identified a small molecular inhibitor of ferroptosis, termed ferrostatin-1 (Fer-1), which appeared to selectively inhibit erastin-induced cell death but not apoptosis or other reactive oxygen species (ROS)-induced forms of cell death