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This endorphin depletion may explain some of the chronic pain issues that often accompany PTSD, and also supports the caution that opioid treatment for this disorder may in fact worsen the condition, as stated by the aforementioned National Institute of Mental Health report

Nucleic Acids Res 51:1076810781 Balasco Serro VH, Minari K, Pereira HD, Thiemann OH (2024) Bacterial selenocysteine synthase structure revealed by single-particle cryoEM