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At first glance, this may seem an appropriate and straightforward way to quantify the treatment effect, but there are several reasons why the placebo-adjusted effect sizes of a drug in RCTs do not necessarily indicate the effect sizes that are achieved in real-life patient management

often used with very low-calorie diets, although not commonly advocated for today

Only mature red blood cells produce haemoglobin, the oxygen carrying metalloprotein (iron-containing protein) that distributes oxygen to all cells of the body

Because acarbose has limited systemic absorption, which results in minimal maternal plasma concentrations, clinically significant exposure via breast milk is not expected