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Some studies examined C57BL/6J mice exposed to aspartame either in utero until lactation or in utero until adulthood

Acetaldehyde was recovered in total blood, liver, kidneys, spleen, heart muscle, and skeletal muscle

Overweight and obesity strongly predispose a person to IIH: women who are more than ten percent over their ideal body weight are thirteen times more likely to develop IIH, and this figure goes up to nineteen times in women who are more than twenty percent over their ideal body weight

While the rodent study was single administration, human PD studies suggest that effects dissipate fairly quickly without ongoing doses