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As the core component of class III phosphatidylinositol 3-kinase complex I (PtdIns3K) [99], BECN1 triggers different cell death by cooperating with different partners, and it is also a factor for occurrence of ferroptosis [100]

In pancreatic cancer, LAT2 ( SLC7A8 ) was shown to decrease gemcitabine sensitivity by regulating glutamine-dependent mTOR activation to promote proliferation and inhibit apoptosis (Feng et al., 2018)

12,13 Oxidation of alpha-1 antitrypsin reduces its ability to inhibit neutrophil elastase, a major factor in the pathogenesis of COPD

These results show the perspective on the early prevention and treatment of HD with metformin