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J Invest Dermatol 103:726730 Bentez-Bribiesca L, Snchez-Surez P (1999) Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes

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This sequence of events is recapitulated in a humanized mouse model of diabetes, in which the presence of autoreactive T-cells alone was insufficient to induce disease, which was triggered only when -cells were stressed by the addition of the diabetogenic agent, streptozotocin (STZ) (32)

Furthermore, the intracellular ATP level is even higher in therapy-resistant cancer cells as compared to its parental drug-sensitive cell line [99, 100]