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Herein, the optimization pathways of existing therapeutics and emerging therapeutic directions are systematically reviewed, with particular emphasis on their mechanisms of action, current clinical application status, and future potential, with the aim of providing guidance for personalized IBD management

Cu homeostasis is also required for the virulence of the fungal pathogen C

For experiments, a working concentration of 4 M was freshly prepared by diluting the stock solution in complete culture medium, yielding a final DMSO concentration of 0.1%

(iii) Stem cellstoxicological tests involving the insertion of disease genes into embryonic stem cells, which then differentiate into human disease tissues that can be further used for drug screening