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The inhibitor concentration necessary for 50% inhibition (IC 50 ) was determined with respect to a control (no inhibitor)

Murakami, H

10.1105/tpc.11.11.2167 93 NajamiN.JandaT.BarriahW.KayamG.TalM.GuyM.et al

However, the reality is that it is very difficult to do that net of fees, implementation costs, and not actively shorting the stocks with the lowest exposure to desirable factors (as was done in the academic research)