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demonstrated that Gln deprivation reduces the levels of key TCA cycle intermediates, thereby inhibiting tumor cell proliferation [51]

Among other issues are differences in capacity and affinity for the oxidizing substrate, a potential role of thiol peroxidases in H 2 O 2 perception and, as mentioned above, the importance of other peroxidases in H 2 O 2 -dependent substrate oxidations or ROS generation