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Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine

Elevated sputum levels of both MUC5AC and MUC5B are consistently observed in the sputum of patients with asthma, COPD, and chronic bronchitis [7], with MUC5AC showing a stronger association with T2/eosinophilic inflammation and airway hyperresponsiveness (AHR) and MUC5B showing a stronger association with airway sensitivity and relatively preserved lung function [53,54,55]