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High glucose (HG) triggered iron overload, antioxidant capability reduction, massive ROS production, and lipid peroxidation in renal tubular cell death (23, 88)

10.1097/MCO.0b013e32834f0078

With the recent broad recognition of click chemistry and bioorthogonal chemistry, we anticipate a surge in research in the years to come, driving further advancements in biocompatible techniques for peptide macrocyclisation and expanding the toolkit of chemical methods for protein and cellular ligation