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doi: 10.1111/pbi.12712 30 DiedrickT

Disclosures: Jasmohan Bajaj: Bausch: Grant/Research Support, Sequana: Grant/Research Support, Cosmo: Grant/Research Support, Grifols: Grant/Research Support, Masoumeh Sikaroodi: Nothing to Disclose, Marcela Pea Rodrguez: Nothing to Disclose, Puneeta Tandon: Nothing to Disclose, Jennifer Lai: Nestle Nutrition Institute: Grant/Research Support, Novo Nordisk: Consultant, Genfit: Consultant, Boehringer Ingelheim: Advisor, Jacqueline Oleary: Grifols: Consultant, Cellion: Advisor, Mallinckrodt: Advisor, PharmaIn: Consultant, Genfit: Consultant, CVS: Stock - publicly traded company, Guadalupe Garcia-Tsao: Nothing to Disclose, Florence Wong: Mallinckrodt: Consultant, Mallinckrodt Pharmaceutical Inc: Grant/Research Support, River 2 Renal: Consultant, Sequana Medical: Consultant, sequana Medical: Grant/Research Support, Hugo Vargas: Sequana Medical: Consultant, Mallinckrodt: Consultant, Ocelot: Grant/Research Support, Arrowhead Phama: Grant/Research Support, Takeda: Grant/Research Support, Durect: Grant/Research Support, River2Renal: Grant/Research Support, Genfit: Grant/Research Support, Kezar Pharmaceuticals: Grant/Research Support, Scott Biggins: Nothing to Disclose, Patrick Kamath: Sequana: Advisor, NovoNordisk: Advisor, Brian Bush: Nothing to Disclose, K Rajender Reddy: Nothing to Disclose, Patrick Gillevet: Nothing to Disclose 1034 DIETARY INTERVENTION IMPROVES INTESTINAL PERMEABILITY AND REDUCES COLON FIBRO-INFLAMMATION IN THE GAN DIET-INDUCED OBESE AND BIOPSY-CONFIRMED MOUSE MODEL OF MASH Susanne Pors 1 Jacob Nhr-Meldgaard 1 Kristoffer Voldum-Clausen 1 Anitta Kinga Sarvari 1 Sakthi Jagadeesan 2 Kasper Almholt 3 Natalia Petersen 3 Charlotta Dornonville de la Cour 3 Sebastian Beck Jrgensen 3 Henrik Hansen 1 Michael Feigh 1 , 1 Gubra, 2 Artus Therapeutics, 3 Novo Nordisk Background: The gutliver axis is considered playing an important role in metabolic dysfunction-associated steatohepatitis (MASH)