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The high cost linked with these complex processes can pose commercial difficulties in peptide drug development

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Keywords: Drug induced liver injury (DILI), Endocrinology, Hepatotoxicity, Idiosyncratic hepatic injury, Risk factors INTRODUCTION A large number of drugs have deleterious effects on liver and drug-induced liver injury (DILI) is a major clinical problem

Differential diagnosis: Histiocytic sarcomahepatic parenchyma infiltrated and replaced by collections of histiocytic cells that can be pleomorphic