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2008 headline: WHO slams e-cigarette marketing In September 2008, the World Health Organization announced that marketers should immediately remove any claims that e-cigs are a safe and effective smoking cessation aid because there is no scientific evidence to confirm the products safety and efficacy. Soon after, a study funded by e-cigarette manufacturer Ruyan declared the product to be 100 to 1,000 times less dangerous than smoking tobacco, adding that when using its device, nicotine is apparently not absorbed from the lung, but from the upper airways. 2010 headline: The battle heats up In May 2009, the Food and Drug Administration released the results of a test of two US e-cig brands, NJOY and Smoking Everywhere, that found very low amounts of nicotine in cartridges labeled as nicotine-free

THC binds to CB1 receptors in the brain because its structure mimics that of endocannabinoids like anandamide and 2-AG

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