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Units are ml.kg -1 It is a way to describe what proportion of a drug is confined to plasma, and what proportion distributes to other tissues It does not correspond to any particular volume, however a V D of: Less than 40ml.kg -1 indicates a drug is confined to plasma Up to 200ml.kg -1 indicates a drug is confined to the ECF Up to 600ml.kg -1 indicates a drug is dissolved into the TBW Greater than 1L.kg -1 indicates a drug is highly protein bound or lipophilic Agents which cross the blood brain barrier typically have a V D of 1-2L.kg -1

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Elamipretide (SS31) (2021)