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People with acne who take high-dose oral vitamin B12 should be aware that, while rare, it could possibly trigger a breakout

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usually mild) Fishy body odor (due to trimethylamine production) Headache (occasional) Increased appetite (some patients) When to Contact Healthcare Provider: Severe GI symptoms Signs of allergic reaction (rash, swelling) Increased seizure frequency (if history of epilepsy) Unusual bleeding or bruising (if on warfarin) Symptoms of hypothyroidism (fatigue, weight gain, cold intolerance) Drug and Supplement Interactions: Warfarin: May increase anticoagulant effect