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Like other antioxidants, lower ascorbate pools in the cell contribute to increase ROS that can considerably damage the photosynthetic apparatus, leading to a faster decline in photosynthetic activity in AsA-deficient tissues, thereby speed up senescence (Barth et al., It is well aasumed that ascorbate-hormone interaction plays a pivotal role in regulation of senescence (Zhang, 2013b)

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MRI and voxel-based morphometry analyses have consistently demonstrated reductions in grey matter volume in key cognitive regions, including the hippocampus, prefrontal cortex, anterior cingulate cortex, and insula in patients with COPD