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Maternal periodontitis expands oral pathobionts like Klebsiella aerogenes , which translocate to the infant gut, disrupt intestinal immunity, and predispose offspring to enteritis ( Gemella and Rothia and decreased Veillonella , with these oral taxa forming distinct ecological clusters in the gut, implying oral-gut migration ( In systemic diseases, oral-gut microbial interactions are prominent

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290,291 Moreover, in Caco-2 cells, zinc depletion was found to cause a decline in TER and an increase in intestinal epithelial permeability